GLP-1 and hormone therapy: questions to ask your prescriber

Write down every medicine you take, including your GLP-1 brand and form (shot, pill, compounded), your hormone therapy type, and your exact schedule. Include supplements, vitamins, and any over-the-counter meds you use often. Add your pharmacy name(s), since pharmacists can help check timing issues. Bring this list to every visit so your clinician is working from the same information you are.

Before your appointment, list your top two or three goals, such as weight management, blood sugar goals, symptom relief, or quality of life. Note which hormone-therapy symptoms you want to improve (for example, hot flashes, sleep, mood, or cycle-related symptoms) and which GLP-1 side effects you are trying to avoid. If you are on GLP-1 for heart or kidney risk reasons, include that context too. Clear goals help your clinician weigh benefits and risks without guesswork.

GLP-1 medicines are generally not recommended during pregnancy, so tell your prescriber if pregnancy is possible now or in the near future. If you use oral contraceptives and you are on tirzepatide (Mounjaro or Zepbound), ask your prescriber about the known issue of reduced oral contraceptive absorption around treatment starts and dose increases. If you are trying to conceive, breastfeeding, or have fertility questions, route those questions to your prescriber or OB-GYN. Do not make changes on your own based on online advice.

Some GLP-1 choices have specific dosing routines that can affect how you plan your morning. If you use the Wegovy pill (oral semaglutide 25 mg), it must be taken first thing in the morning with a small sip of water, at least 30 minutes before food, drinks, or other oral medicines. If you use Foundayo (orforglipron), it can be taken once daily at any time of day with no fasting or water restrictions. Ask your pharmacist or prescriber how to fit your hormone therapy and other morning meds into your routine without guessing.

Many symptoms can have more than one cause, so simple tracking can help your clinician problem-solve. For 2–4 weeks, jot down nausea, constipation or diarrhea, appetite changes, sleep changes, mood shifts, headaches, and cycle changes (if relevant), plus when you took your meds. Note any patterns around injection days, pill timing, or hormone-dose days. Bring the log to your appointment so the discussion is based on data, not memory.

If you are considering switching formulations (shot vs pill) or starting a newly approved option, ask what prior authorization or follow-up is usually needed. As of June 30, 2026, newer options include the Wegovy pill (oral semaglutide 25 mg) and Foundayo (orforglipron), which may be available through channels like LillyDirect, telehealth, and retail pharmacies. If cost is a concern, ask about manufacturer programs and confirm current pricing and eligibility directly with the manufacturer, your plan, or your pharmacist, since programs change often. If you are using a compounded version, ask your prescriber what monitoring they want and how they prefer side effects and supply issues be handled.